Understanding methylation and mthfr: what it means for your health

WHAT IS METHYLATION?

Methylation is a VITAL biochemical process that occurs in every cell of your body. It involves the addition of a small chemical group called a methyl group (one carbon atom bonded to three hydrogen atoms) to DNA, proteins, and other molecules. This process helps regulate gene expression, supports detoxification, balances neurotransmitters, and assists in DNA repair and immune function.

WHY IS METHYLATION IMPORTANT?

Key functions of Methylation:

  • Regulates gene expression.

  • Repairs and builds DNA/RNA.

  • Plays a key role in foetal development and pregnancy.

  • Reduces histamine load.

  • Produces energy.

  • Essential for neurotransmitter balance (eg: mood, sleep, cognition).

  • Contributes to myelination of nerves, brain development, and cognitive health.

  • Supports liver detoxification.

  • Facilitates hormone metabolism.

  • Maintains telomere integrity (aging).

  • Builds and regulates immune cells.

  • Modulates stress response.

WHAT IS MTHFR?

MTHFR stands for methylenetetrahydrofolate reductase, an enzyme critical to the methylation cycle. It converts folate (vitamin B9) into its active form, 5-MTHF (5-methyltetrahydrofolate), which is essential for methylation and for producing neurotransmitters like serotonin and dopamine.

MTHFR Gene Variants and Their Impact

Some people carry genetic variations (commonly called polymorphisms) in the MTHFR gene that reduce the efficiency of this enzyme. The most common variants are C677T and A1298C. These variants can lead to:

  • Reduced ability to convert folate into its active form

  • Impaired methylation capacity

  • Elevated homocysteine levels, a marker associated with cardiovascular risk

  • Challenges with detoxification and neurotransmitter balance

How Does MTHFR Affect Your Health?

When methylation is compromised due to MTHFR variants or other factors, it may contribute to a wide range of health concerns, including:

  • Fatigue, anxiety, depression, insomnia.

  • Hormonal imbalance.

  • Histamine intolerance.

  • Neurological issues (eg: poor memory, ADHD/Autism-like symptoms).

  • Low immunity or frequent infections.

  • Poor detox capacity.

  • Infertility or poor pregnancy outcomes.

  • Accelerated aging.

Supporting Methylation and MTHFR Health

While genetic predisposition cannot be changed, lifestyle and targeted Naturopathic support can optimize methylation function and overall health. This may include:

  • Ensuring adequate intake of essential nutrients to support healthy methylation

  • Supporting gut health for better nutrient absorption

  • Managing stress and supporting nervous system balance

  • Reducing environmental toxin exposure

  • Tailoring supplementation based on individual genetic and biochemical testing

  • Addressing pathway functionality and reducing the impact of polymorphisms

Do you have some questionS?

Have you heard about MTHFR but not sure if it is something that you need to look into?

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